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Validation of a Novel Telehealth Administration Protocol for the NIH Toolbox-Cognition Battery.

Validation of a Novel Telehealth Administration Protocol for the NIH Toolbox-Cognition Battery.

Validation of a Novel Telehealth Administration Protocol for the NIH Toolbox-Cognition Battery.

Telemed J E Health. 2018 Jun 21;:

Authors: Rebchuk AD, Deptuck HM, O'Neill ZR, Fawcett DS, Silverberg ND, Field TS

Abstract
BACKGROUND: Cognition is an important outcome in many clinical trials. The NIH Toolbox-Cognition Battery (NIHTB-CB) is a computerized cognitive assessment designed for clinical research that is administered in-person. Here, we evaluated the equivalency of a novel videoconference protocol for administering the NIHTB-CB. Since our protocol required repeated assessments, we further explored the NIHTB-CB's practice effect.
MATERIALS AND METHODS: Twenty-five healthy participants completed the NIHTB-CB under two separate conditions 4 weeks apart. The standard condition followed the recommended administration protocol, whereas the videoconference condition had the examiner and participant in separate rooms but able to communicate over videoconference. A linear mixed-model analysis was performed to explore the fixed effect of testing condition and time on NIHTB-CB performance.
RESULTS: Across all three NIHTB-CB composite scores (total, fluid, and crystallized cognition), no significant fixed effect of administration condition was found. A significant practice effect was observed for the fluid and total cognition composite scores over a 29.0 (±2.1) day test-retest interval.
CONCLUSIONS: Our novel videoconference protocol for the NIHTB-CB is equivalent to the standard protocol in healthy participants, and may provide a solution for researchers seeking to engage study participants at remote sites. If the NIHTB-CB is used longitudinally to monitor patients, corrections for repeated measures may be required.

PMID: 29927713 [PubMed - as supplied by publisher]

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